Pwntools, PIE and ROP

As shown in the pwntools ELF tutorial, pwntools has a host of functionality that allows you to really make your exploit dynamic. Simply setting elf.address will automatically update all the function and symbols addresses for you, meaning you don't have to worry about using readelf or other command line tools, but instead can receive it all dynamically.

Not to mention that the ROP capabilities are incredibly powerful as well.